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Stabilize biological samples
Heat stabilization permanently inhibits enzymatic activity
- Get closer to original in vivo profiles
- Discover novel proteins and peptides
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Prepare, analyze and re-analyze without risk of degradation
- minimize inter-sample variation
- improve data interpretation
The StabilizorTM system uses rapid heating to retain the in vivo state of biological samples from the moment of sampling. Heat stabilization preserves the composition of proteins, peptides and post-translations modifications, permanently prevents post mortem changes and thereby increases the accuracy and quality of analytical results.
Using the Stabilizor system to heat-stabilize samples:
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Eliminates enzyme activity from the moment of sampling
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Stops degradation permanently - without using additives
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Standardizes sample handling - to improve reproducibility of analytical workflows
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Links upstream processing to downstream results - traceable treatment parameters
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Facilitates accurate sample comparison and data interpretation downstream
Biological samples successfully analyzed
The range of biological samples that have been heat-stabilized and analyzed successfully is expanding steadily as more scientists implement the Stabilizor system into their workflows. Currently, the benefits of heat-stabilization have been utilized when analyzing proteins or peptides in the following biological samples:
Proteins in brain, liver, heart, pancreas and breast tumor, erythrocytes and yeast.
Peptides in brain, thymus and pancreas.
Analytical techniques have included mass spectrometry, Western Blot with phospho-specific antibodies, 1D and 2D gels with phospho-specific stains and reversed phased protein arrays (RPPA)
Ordering information
Please contact your local Denator representative.
